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"In this study, we constructed lentiviral vectors expressing constitutively active Akt1 and Akt3, two major isoforms of Akt, which reduced brain infarction in rats We found that overexpression of Akt1 and Akt3 not only promoted protein phosphorylation in the Akt pathway, including p-Akt, p-PTEN, and p-FKHR, but also promoted mTOR phosphorylation in the mTOR pathway."