IndraLab

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IFNG increases the amount of USP18. 4 / 4
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"IFN-gamma signaling induces USP18 expression in tumor cells during immunosurveillance."
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"In this report, we investigated the function of USP18 in IFN-gamma signaling in B16 melanoma cells in vitro and in vivo and found that IFN-gamma or CTLs activated USP18 expression in tumor cells."
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"USP18 expression in tumor cells, such as human sarcoma 2fTGH cells, is not only induced by IFNgamma timulation [XREF_BIBR]."
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"In conclusion, we found that IFN-gamma signaling induces intrinsic expression of USP18 in tumor cells that not only affects tumorigenesis, but also may be useful in regulating immunotherapy efficacy."
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