IndraLab

Statements

USP3 inhibits RIGI. 7 / 9
| 7
reach
"USP3, USP21, and CYLD suppress RIG-I activation by removing the K63 polyubiquitin chain on the N-terminal CARD of RIG-I [ 19–21 ]."
31806368
reach
"While the deubiquitinase USP3 inhibits MDA5 as well as RIG-I, it is thought that this may be due to USP3 directly binding the MDA5 CARD domain to prevent RNA filamentation (284)."
31379819
reach
"Our findings identify a previously unrecognized role of USP3 in RIG-I activation and provide insights into the mechanisms by which USP3 inhibits RIG-I signaling and antiviral immunity."
24366338
reach
"The deubiquitinases USP3 and USP21 inhibit RIG-I activity by removing K63-linked ubiquitin chains."
| PMC
reach
"Both USP3 and USP21 negatively regulate RIG-I activation via the cleavage of Lys63-linked Ubs conjugated on the 2CARD [ 51,52 ]."
25594890
reach
"In particular, USP3, USP21, USP25 and USP15 have all been shown to directly inhibit RIG-I."
28295214
reach
"Conversely, the removal of Lys63-linked ubiquitylation by the cellular deubiquitylating enzymes (DUBs) ubiquitin C-terminal hydrolase 3 (USP3), USP21 and CYLD, represses RIG-I signalling (reviewed in Ref."
27174148