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Oroxylin A(1-) inhibits NLRP3. 20 / 20
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"NLRP3 dependent caspase-1 activation and the secretion of IL-1beta were dose-dependently inhibited by oroxylin A."
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"Moreover, the mRNA expressions of NLRP3 and IL-1beta were also inhibited by oroxylin A in a dose dependent manner, suggesting that oroxylin A might inhibit NLRP3 inflammasome activation via affecting the priming step."
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"These findings suggested that oroxylin A inhibited NLRP3 inflammasome activation and subsequent IL-1beta secretion in THP-Ms."
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"Taken together, these data indicated that oroxylin A inhibited NLRP3 inflammasome activation in BMDMs."
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"Oroxylin A blocked NLRP3 inflammasome activation through inhibiting the NF-kappaB signaling."
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"Next, we investigated the underlying mechanisms which the oroxylin A inhibited NLRP3 inflammasome activation."
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"These results illustrated that oroxylin A inhibited NLRP3 inflammasome activation through blocking NF-kappaB signaling."
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"The above results demonstrated that oroxylin A could inhibit NLRP3 inflammasome activation via suppression of the priming step."
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"Therefore, we confirmed that oroxylin A could down-regulate the activation of NLRP3 inflammasome, with decreased levels of caspase-1, IL-1beta and NLRP3 in colon samples of DSS induced colitis mice."
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"Taken together, we concluded that oroxylin A inhibited the activation of NLRP3 inflammsome by blocking NF-kappaB signaling."
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"To confirm the results of in vivo study, two types of macrophages were used here, and it was found that oroxylin A could down-regulate the activation of NLRP3 inflammasome in both THP-1-derived macrophages and BMDMs."
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"Furthermore, we also observed the negative effect of oroxylin A on cytosolic assembly of ASC speck after inflammasome activation, suggesting that oroxylin A could also block the formation of NLRP3 inflammasome."
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"Results illuminated that oroxylin A inhibited NLRP3 inflammasome activation by reducing ROS accumulation."
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"The levels of TNF-α, IL-1β, and IL-6 in colons were also notably lowered by oroxylin A. Moreover, oroxylin A prominently inhibited the NLRP3 level in gut mucosa tissues."
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"By contrast, a recent study by Zhou and colleagues showed that Nlrp3 inhibition by the flavonoid oroxylin A may have beneficial effects against colitis in DSS treated mice."
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"Oroxylin A inhibits colitis by inactivating NLRP3 inflammasome."
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"Our findings demonstrated that oroxylin A inhibited NLRP3 inflammasome activation and could potentially be used for the treatment of IBD."
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"In this study, we found that oroxylin A remarkably attenuated the symptoms of murine colitis and decreased the activation of NLRP3 inflammasome induced by DSS in colitis model."
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"Taken together, these findings suggested that oroxylin A markedly suppressed NLRP3 inflammasome activation through inhibiting NF-kappaB pathway in vivo."
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"Oroxylin A inhibited NLRP3 inflammasome activation in THP-Ms and BMDMs."
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