IndraLab

Statements

USP18 activates Ubiquitin. 3 / 3
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"A novel interferon stimulated gene encoding a 43-kDa ubiquitin specific protease, designated ISG43, was identified in this screen."
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"Overall, our study and other studies indicate that USP18 recruits distinct E3 ubiquitin ligases to mediate different ubiquitin linkage types of targeted proteins for regulating its functions, facilitating the balance of immune responses and the maintenance of homeostasis.In summary, we identified USP18 as a negative regulator of pyroptosis by promoting the autophagic degradation of GSDMD."
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"A similar role of RNAse L negative regulation of the IFN response has also been suggested by the report that a novel IFN-stimulated gene encoding a 43-kDa ubiquitin-specific protease, designated ISG43[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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