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SP1 binds OTUB2. 6 / 6
1 | 2 3
sparser
"Additionally, the results from endogenous and exogenous co-immunoprecipitation (CO-IP) experiments further supported the interaction between OTUB2 protein and SP1 protein (Fig.  xref C, D)."
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reach
"Confocal microscopy results also revealed the binding between OTUB2 and SP1 in colon cancer cells (Fig. 5B)."
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reach
"Second, while we have demonstrated that OTUB2 can inhibit K48 ubiquitination-mediated degradation of SP1 and upregulate its expression, it remains unknown whether OTUB2 competitively binds to the ubiquitin or E3 ubiquitin ligase binding site on SP1."
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sparser
"OTUB2 interacted with SP1 to suppress its K48 ubiquitination, thereby upregulating its protein expression level."
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sparser
"First, although we have shown that SP1 is a target protein of OTUB2, we have not further identified the specific structural domain or binding site where OTUB2 interacts with SP1."
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biogrid
No evidence text available
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