IndraLab

Statements

USP7 increases the amount of FOXP3. 4 / 4
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"These authors have also shown that the overexpression of USP7 in Tregs increases Foxp3 protein levels (40)."
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"USP7 is upregulated in Treg cells, and the ectopic expression of USP7 decreases Foxp3 polyubiquitylation and increases Foxp3 expression."
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"The knockdown of USP7 decreased the levels of endogenous FOXP3 and diminished the Treg suppressive activity while ectopic expression of USP7 increased FOXP3 expression by preventing its degradation."
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"Our present findings suggest that targeting factors such as USP44 and USP7 that promote FOXP3 expression at the protein level is a strategy that offers exciting possibilities for the fine tuning of immune responses in cancer."
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