IndraLab

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Parthenolide inhibits RELA. 16 / 22
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"Parthenolide, a major sesquiterpene lactone from the plant Tanacetum parthenium, inhibits NF-kappaB both indirectly, by inhibiting the IkappaB kinase (IkappaK), and directly, by modifying p65 at a key cysteine residue in its activation loop [XREF_BIBR, XREF_BIBR]."
23039130
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"The sesquiterpene lactone parthenolide inhibits NF-kappaB by alkylating p65 at Cys."
26239915
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"These findings confirmed the involvement of NF-κBp65 inhibition by parthenolide or AuNPs via modulation of hsa-miR-204-5p and MMP-9 expression."
37372062
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"Contrary to previous reports, we show that parthenolide, like other SLs, inhibits NF-kappaB most probably by alkylating p65 at Cys (38)."
11500489
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"We demonstrated that parthenolide inhibited constitutive and paclitaxel induced RelA and NF-kappaB activity by interfering with the effect of paclitaxel on IKK-beta, thereby functionally inhibiting phosphorylation of I-kappaBalpha and subsequently leading to inhibition of NF-kappaB activity."
19067767
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"However, parthenolide, a sesquiterpeno lactone that inhibits RelA activation by preventing the degradation of IkappaB-alpha XREF_BIBR, XREF_BIBR did not prevent p100 processing (XREF_FIG)."
20126461
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"Mechanistic investigation showed that parthenolide could inhibit the NF-κB signaling pathways by directly targeting IKKβ or p65 [15]."
35866602
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"Both LY294002 and parthenolide inhibited EGF induced nuclear accumulation of NF-kappaB p65."
23383347
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"On the other hand, treatment with 20 μM Parthenolide (a potent inhibitors of NFκB signaling pathways), suppressed the binding of p65 to the NFκB sites by 75% as compared to LPS-induced cells ( Fig. 4 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25981112
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"The results showed that the p65 activity was more enhanced by Gem resistance in both cell lines, and that parthenolide significantly reduced the p65 activity."
38474833
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"To confirm the involvement of NF-κBp65 inhibition by parthenolide via modulation of hsa-miR-204-5p and MMP-9 expression."
37372062
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"In AsPC-1 GS and GR cells, treatment with parthenolide decreased the p65 activity by 71.5% and 85.9%, respectively, compared to the control, and treatment with parthenolide also decreased the p65 activity, which was increased by TNF-α, by 51.8% and 85.9%, respectively."
38474833
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"The p65 activities of MIA PaCa-2 GS and GR cells were decreased by 61.6% and 47.9%, respectively, by the parthenolide treatment compared to the control, and the p65 activities increased by TNF-α were also decreased by 71.7% and 16.5%, respectively, by the parthenolide treatment."
38474833
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"To test the hypothesis that activation of NF-kB is necessary for the inhibition of cell proliferation by chloroquine and 6-AN, we treated the cells with parthenolide, which inhibits both p65 and RelA and caspase-1 via alkylation 16."
24296756
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"To test the hypothesis that activation of NF-kB is necessary for the inhibition of cell proliferation by chloroquine and 6-AN, we treated the cells with parthenolide, which inhibits both p65 and RelA and caspase-1 via alkylation 16."
24296756
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"Tissue microarray of mouse tumors showed that parthenolide decreased scores of the cell proliferation marker Ki67 and p65 and NF-kB, whereas it increased p21 expression."
23037503