IndraLab

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Parthenolide inhibits RELA. 9 / 9
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"To test the hypothesis that activation of NF-kB is necessary for the inhibition of cell proliferation by chloroquine and 6-AN, we treated the cells with parthenolide, which inhibits both p65 and RelA and caspase-1 via alkylation 16."
24296756
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"We demonstrated that parthenolide inhibited constitutive and paclitaxel induced RelA and NF-kappaB activity by interfering with the effect of paclitaxel on IKK-beta, thereby functionally inhibiting phosphorylation of I-kappaBalpha and subsequently leading to inhibition of NF-kappaB activity."
19067767
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"To test the hypothesis that activation of NF-kB is necessary for the inhibition of cell proliferation by chloroquine and 6-AN, we treated the cells with parthenolide, which inhibits both p65 and RelA and caspase-1 via alkylation 16."
24296756
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"Both LY294002 and parthenolide inhibited EGF induced nuclear accumulation of NF-kappaB p65."
23383347
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"However, parthenolide, a sesquiterpeno lactone that inhibits RelA activation by preventing the degradation of IkappaB-alpha XREF_BIBR, XREF_BIBR did not prevent p100 processing (XREF_FIG)."
20126461
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"Parthenolide, a major sesquiterpene lactone from the plant Tanacetum parthenium, inhibits NF-kappaB both indirectly, by inhibiting the IkappaB kinase (IkappaK), and directly, by modifying p65 at a key cysteine residue in its activation loop [XREF_BIBR, XREF_BIBR]."
23039130
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"The sesquiterpene lactone parthenolide inhibits NF-kappaB by alkylating p65 at Cys."
26239915
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"Contrary to previous reports, we show that parthenolide, like other SLs, inhibits NF-kappaB most probably by alkylating p65 at Cys (38)."
11500489
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"Tissue microarray of mouse tumors showed that parthenolide decreased scores of the cell proliferation marker Ki67 and p65 and NF-kB, whereas it increased p21 expression."
23037503