IndraLab

Statements

USP18 inhibits IFN-lambda. 3 / 3
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eidos
"For example , the ISG USP18 desensitizes cells to further IFN-alpha stimulation but does not inhibit IFN-lambda signaling ( Fran c ois-Newton et al ., 2011 ) ."
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eidos
"The reason for this paradox is unknown , but IFN-lambda4 has been speculated to render HCV-infected hepatocytes refractory to IFN-alpha , for example by inducing the expression of USP18 , which inhibits IFN-alpha but not IFN-lambda signaling41 ."
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reach
"The reason for this paradox is unknown, but IFN-lambda4 has been speculated to render HCV infected hepatocytes refractory to IFN-alpha, for example by inducing the expression of USP18, which inhibits IFN-alpha but not IFN-lambda signaling XREF_BIBR."
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