IndraLab

Statements

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"USP8 promotes CSCC progression by enhancing tumor invasion capacity."
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"In addition, USP8 depletion inhibited the proliferation, invasion and stemness of HCC cells and conferred ferroptosis resistance, which effects could be further rescued by beta-catenin overexpression."
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"It indicated that migration and invasion ability of shUSP8 iCCA cells were weakened (Fig. 5E, F) but USP8-overexpressing promoted the migration and invasion ability by transwell assay (Figure S1C)."
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"Elevated levels of USP8 led to cell proliferation, migration, and invasion of CSCC cell lines."
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"USP8 promotes TGF-β/SMAD-induced EMT, invasion, metastasis, and facilitates TβRII circulating EVs to induce TEX and chemoimmunotherapy resistance (92)."
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"Transwell assay demonstrated that knockdown of USP8 dramatically decreased the invasion capacity of LM3 and HepG2 cells (Fig. 5E)."
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"Meanwhile, USP8 deficiency could reduce tumor invasion and migration and tumor size in an immunity-dependent manner, and improve anti-tumor immunogenicity."
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"Our work showed that USP8 silencing promoted ESCC cell apoptosis and inhibited cell invasion, migration, stem‐like cell properties, and glucose metabolism."
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"USP8 deficiency significantly reduces tumor migration and invasion and improves anti-tumor immunogenicity."
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"USP8 inhibition significantly reduced KPC and BxPC-3 cell invasion and migration (Fig. S2a–d)."
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"Cellular studies showed that USP8 can enhance the proliferation, migration, and invasion abilities of CSCC cells, thereby promoting tumor progression."
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"However, both the migration and invasion capacities of CSCC cells were upregulated by USP8 overexpression (XREF_FIG)."
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"Moreover, we conducted cellular studies and found that USP8 can significantly upregulate the migration and invasion processes of CSCC cell lines."
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"In conclusion, we demonstrated that USP8 in cancer tissue is an independent prognostic biomarker of CSCC, and high USP8 in CSCC can enhance cell invasion."
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"HuR at the post-transcriptional level increased the level and stability of USP8 mRNA and facilitated translation of USP8 protein, promoting the proliferation, migration, and invasion of NSCLC cells."
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"Knockdown of USP8 inhibited the proliferation, migration, invasion, and cell cycle progression of A549 and H1299 cells, and promoted the apoptosis."
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"Inhibition of USP8 led to diminished tumor invasion, migration, and overall tumor size, enhancing anti-tumor immunity."
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"USP8 promotes TGF-β/SMAD-induced epithelial-mesenchymal transition (EMT), invasion, and metastasis in tumor cells."
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"Our findings indicated that the proliferation , invasion , and stemness of LN229 and T98G cells were markedly suppressed by USP8 inhibition ."
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"USP8 also promotes epithelial-mesenchymal transition (EMT), invasion, and metastasis of tumor cells in response to TGF-β/SMAD signaling."
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"Knockdown of USP8 Inhibits the Migration and Invasion of Lung Cancer Cells."
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"Finally, USP8 could promote tumor proliferation, invasion and stem-like properties of HCC through β-catenin."
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"Knockdown of USP8 significantly inhibited tumor proliferation, invasion, and stem-like properties."
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"Conversely, overexpression of hnRNPU promoted USP8 expression in 786-O cells and enhanced their invasion."
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"Consistent with our previous observations of DUB‐IN‐3, knockout of USP8 significantly suppressed the proliferation, invasion, and stemness of HCC cells (Figure S1, Supporting Information)."
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"In addition, in cervical squamous cell carcinoma (CSCC), USP8 enhanced the proliferation, migration, and invasion of cervical squamous cells, thereby promoting the progression of CSCC [18] ."
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"The migration of the USP8-overexpressing cells was significantly increased compared to the USP8-vector group ( Fig. 2 B) and the invasion assay showed that the upregulation of USP8 significantly incre[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, the migration and Transwell invasion assays confirmed that the upregulation of USP8 could reverse the attenuation of trophoblast migration and invasion caused by SCNN1A silencing ( Fig. 5 B,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Consistent with the results identified above, USP8 WT promoted the proliferation, invasion, and stemness of HCC cells, but the C786A and S716A mutants lost these abilities (Figure 6H–L; Figure S7A–D, Supporting Information)."
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"It was found that USP8 positively regulated the proliferation and invasion of trophoblast cells and stabilized the ENaC expression on the cell membrane."
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"It was also found that USP8 can significantly upregulate the migration and invasion process of CSCC [18] ."
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"Depletion of USP8 Inhibits Cell Proliferation, Migration, and Invasion in BC In Vitro."
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"Our findings indicated that the proliferation, invasion, and stemness of LN229 and T98G cells were markedly suppressed by USP8 inhibition."
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"In the current research, we found a reduction of USP8 in the trophoblast tissue and cells of PE, and that USP8 overexpression can remarkably increase the growth, migration, and invasion rates of troph[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP8 also promotes tumor metastasis, invasion, and epithelial‐mesenchymal transition in response to TGF‐β/SMAD signaling."
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"Studies have shown that USP8 can promote migration and invasion in tumors."
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