IndraLab

Statements

EZH2 binds BAP1. 5 / 5
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"BAP-1 interactions with histone deacetylase (HDAC) and enhancer of zeste homolog 2 (EZH2) have been exploited to suppress MPM progression."
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"The interaction of BAP1 and EZH2 and the efficacy of tazemetostat show great potential for the future of cancer treatment for patients harboring variants in those genes due to the more aggressive nature of those tumors and the lack of targeted treatments."
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"Survival analysis revealed that BAP1 loss, but not high EZH2 expression, was associated with a better prognosis."
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"We did not identify an interaction between BAP1 and EZH2 by co-immunoprecipitation (XREF_FIG)."
26437366
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"In these lung-iPSCs, the expression of EZH2 (the main component of PRC2 complex) is also very high, and the physical interactions of AXSL proteins with EZH2 and BAP1 is also reported [ xref , xref , xref ]."
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