IndraLab

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MEF2A increases the amount of HCN4. 3 / 3
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"Interestingly, we found that inhibition of MEF2A could significantly decrease the transcription of HCN4 in iPSC-CMs (Supplementary Fig. S7C)."
36653336
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"Although we did not directly test for an interaction between HDAC and Mef2 on the R2R3 enhancer and there are other possible mechanisms that might explain our findings, one unifying hypothesis is that activation of Hcn4 expression by Mef2 is regulated by HDAC activity."
23085412
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"Transgenic overexpression of a dominant negative Mef2 protein causes a reduction in Hcn4 levels in the embryonic heart."
23085412