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Dihydrogen inhibits KCNK2. 2 / 2

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"This pocket has been reported to serve as a detector for multiple physiological stimuli and regulates the C-type gates in other K2P channels; for example, it is involved in the activation of TREK1 and TREK2 by ML335, a K2P channel opener (22, 34), proton-induced inhibition of TASK2 and TALK2 (20, 28), and membrane-tension-sensing of TRAAK (14)."

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"DEPC has been shown to prevent inhibition of TREK1 by protons ( xref ), thus leading to an increased current density at physiological pH e ."

20605797

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Dihydrogen inhibits KCNK2. 2 / 2

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