IndraLab

Statements

HaTx inhibits KCNB1. 4 / 4
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"Thus, HaTx inhibits the drk1 K+ channel, not by physically occluding the ion conduction pore, but by modifying channel gating."
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"To test further if the substituting KcsA pore is indeed under the control of the voltage sensors, we made a chimera between KcsA and the DRK1 (K V 2.1) voltage gated K + channel, because DRK1 is inhibited by HaTx."
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"We studied the mechanism by which Hanatoxin (HaTx) inhibits the drk1 voltage gated K+ channel."
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"Since HaTx inhibits DRK1 by hindering the movement of gating charges, the HaTx sensitivity of the chimera indicates that its gate remains under control of the voltage sensors."
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