IndraLab

Statements

FOXM1 activates OTUB1. 3 / 4
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reach
"18 In here, we not only show that the potent oncogene FOXM1 is a target of OTUB1 but also present evidence to demonstrate that the oncogenic and genotoxic functions of OTUB1 depend on the expression of a functional FOXM1, suggesting that OTUB1 promotes cell proliferation and epirubicin resistance predominantly through targeting FOXM1."
26148240
reach
"Together, these results suggest that the suppression of FOXM1 degradation by OTUB1 in response to epirubcin requires its deubiquitinating catalytic activity, further confirming that FOXM1 is a novel target of the deubiquitinase OTUB1."
26148240
reach
"These results indicate that FOXM1 is a key target of OTUB1 and that FOXM1 mediates the oncogenic and DNA damage resistant functions of OTUB1."
26148240