IndraLab

Statements

FOXM1 activates OTUB1. 5 / 6
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"These results indicate that FOXM1 is a key target of OTUB1 and that FOXM1 mediates the oncogenic and DNA damage resistant functions of OTUB1."
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"Together, these results suggest that the suppression of FOXM1 degradation by OTUB1 in response to epirubcin requires its deubiquitinating catalytic activity, further confirming that FOXM1 is a novel target of the deubiquitinase OTUB1."
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"FOXM1, a previously identified substrate of OTUB1 (Wang et al., 2016), mediates this effect of OTUB1 in RCC."
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"Overexpressing FOXM1 rescues the defects in OTUB1 knockdown RCC cells."
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"18 In here, we not only show that the potent oncogene FOXM1 is a target of OTUB1 but also present evidence to demonstrate that the oncogenic and genotoxic functions of OTUB1 depend on the expression of a functional FOXM1, suggesting that OTUB1 promotes cell proliferation and epirubicin resistance predominantly through targeting FOXM1."
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