IndraLab

Statements

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"The demonstration that a local production of PA could activate TREK-1 [24] convincingly established the existence of lipid gradients within the membrane [21]."
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"PA appears to activate TREK-1 as phospholipase D2 (PLD2) directly binds to TREK-1 and activates the channel through local production of lipid."
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"For example, phospholipase D2 (PLD2) rapidly (<1 ms) translocates in response to membrane stress, subsequently generating phosphatidic acid (PA) that could directly activate TREK1, though it has yet to be explored what, if any, effects Piezo1 may have on PLD2 activity ."
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"The mechanism suggests that TREK1 is activated by phosphatidic acids that are produced via a mechanosensitive motion of PLD2 to PIP2-enriched domains."
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"Then, PLD2 hydrolyzes phosphatidylcholine to choline and phosphatidic acid (PA), which activates TREK1 and its homolog TRAAK and induces potassium influx, leading to unconsciousness and analgesia [6]."
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"Then, PLD2 hydrolyzes phosphatidylcholine to choline and phosphatidic acid (PA), which activates TREK1 and its homolog TRAAK and induces potassium influx, leading to unconsciousness and analgesia [6]."
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"For example, phospholipase D2 (PLD2) rapidly (<1 ms) translocates in response to membrane stress, subsequently generating phosphatidic acid (PA) that could directly activate TREK1, though it has yet to be explored what, if any, effects Piezo1 may have on PLD2 activity ."
38854150
sparser
"For example, phospholipase D2 (PLD2) rapidly (<1 ms) translocates in response to membrane stress, subsequently generating phosphatidic acid (PA) that could directly activate TREK1, though it has yet to be explored what, if any, effects Piezo1 may have on PLD2 activity xref – xref ."
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"At the cytoplasmic face, PA and PE lipids compete to modulate the conformation of the TREK1 TM4 gating helix."
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"77 An example of a direct activator includes intracellular lysophosphatidic acid, which has been previously shown to directly activate TREK1, TREK2 and TRAAK channels.76 Phosphatidic acid (PA) has also been shown to activate a chimeric K channel (voltage sensor domain of K 2.1 fused with a K 1.2 pore domain).78 On the other hand, indirect activation mediated through PLD2 produces multiple products such as phosphatidic acid (PA), phosphatidylglycerol (PG) and phosphatidylethanol (PEtOH)."
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"The activatory effect is proposed to result from PIP 2 being hydrolyzed to PA by phospholipase D2 bound to the C-terminus of TREK channels, with the increase in local concentration of PA directly activating TREK-1 ( xref ); by contrast, the inhibitory effect is proposed to result from PIP 2 competing PA out of its activatory site, implying that PA may be the main channel activator, not PIP 2 ( xref )."
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