IndraLab

Statements

reach
"The demonstration that a local production of PA could activate TREK-1 [24] convincingly established the existence of lipid gradients within the membrane [21]."
31672538
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"PA appears to activate TREK-1 as phospholipase D2 (PLD2) directly binds to TREK-1 and activates the channel through local production of lipid."
28793254
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"77 An example of a direct activator includes intracellular lysophosphatidic acid, which has been previously shown to directly activate TREK1, TREK2 and TRAAK channels.76 Phosphatidic acid (PA) has also been shown to activate a chimeric K channel (voltage sensor domain of K 2.1 fused with a K 1.2 pore domain).78 On the other hand, indirect activation mediated through PLD2 produces multiple products such as phosphatidic acid (PA), phosphatidylglycerol (PG) and phosphatidylethanol (PEtOH)."
34139216
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"At the cytoplasmic face, PA and PE lipids compete to modulate the conformation of the TREK1 TM4 gating helix."
36841877