IndraLab

Statements

USP30 activates PINK1. 4 / 4
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"More specifically, USP30 has been reported to mediate Parkin and PINK1-dependent mitophagy following the acute depolarization of the mitochondria [9] via the deubiquitylating Parkin substrates in the mitochondria [10]."
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"Together, these data highlight the specificity of ntc and USP30 as important and opposing regulators of basal mitophagy.Given the previously established links between FBXO7 and USP30 with toxin-induced PINK1/Parkin mitophagy in cultured human cells, we next analysed whether the induction of basal mitophagy by ntc overexpression or USP30 knockdown involved the Pink1/parkin pathway in vivo."
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"Indeed, we found that pharmacological inhibition of the mitochondrial deubiquitinase USP30 slightly decreased both the PINK1 input threshold and delay multiplier (Figures S6B–S6E)."
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"Knockdown of USP30 rescues the defective mitophagy caused by pathogenic mutations in parkin and improves mitochondrial integrity in parkin- or PINK1 deficient flies."
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