IndraLab

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USP30 activates PINK1. 2 / 2

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"Knockdown of USP30 rescues the defective mitophagy caused by pathogenic mutations in parkin and improves mitochondrial integrity in parkin- or PINK1 deficient flies."

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"More specifically, USP30 has been reported to mediate Parkin and PINK1-dependent mitophagy following the acute depolarization of the mitochondria [9] via the deubiquitylating Parkin substrates in the mitochondria [10]."

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INDRA sources:

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IndraLab

Statements

USP30 activates PINK1. 2 / 2

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