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STAM binds STAMBP. 68 / 73
19 2 | 20 27
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"Based on the NMR structure of AMSH and STAM complex (PDB ID: 5IXF) from H. sapiens , Hologne et al. considered that the interaction of AMSH-SBM and STAM-SH3 contributed to the correct positioning of polyubiquitin chains toward AMSH before cleavage [ xref , xref ]."
35883466
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"Recent studies have shown that the presence of STAM increases the efficiency of Lys63-linked polyubiquitin chain cleavage by AMSH, which binds STAM through its SBM."
27725184
sparser
"Thus, the STAM-AMSH complex can bind up to three ubiquitin molecules ( xref )."
40157538
sparser
"A further link to receptor signaling is provided by AMSH ( a ssociated [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11911875
biogrid
No evidence text available
16431367
biogrid
No evidence text available
16431367
reach
"We have confirmed a previously reported interaction between AMSH and STAM, a protein which is in dynamic equilibrium between cytosol and endosomal membranes."
15314065
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"The observations that STAM interacts with AMSH ( xref ; xref ), a DUB specifically involved in K63Ub chain disassembly ( xref ), and that ubiquitylated forms of both STAM and Hrs accumulate in AMSH −/− cells ( xref ; xref ) suggest that ESCRT proteins may also be modified by K63Ub chains in mammals."
22493318
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"A good example is the association of AMSH with STAM, which can serve to couple enzyme activity to its endosomal localization."
16996268
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"Additionally, our biochemical data show that STAM1 binding to STAMBP facilitates substrate binding and enhances its activity, whereas binding of CHMP3 does not relieve autoinhibition or enhance activity."
40441142
sparser
"The results demonstrated that STAMBP can directly bind to STAM but not EGFR (Supplementary figure 6), suggesting that the regulation occurs in an indirect manner."
34102455
sparser
"Whereas human AMSH binds the ESCRT-0 subunit STAM, AMSH3 binds the ESCRT-I component VPS23A ( xref ), suggesting that both human and plant AMSH proteins could be supporting nucleation of ESCRT-III filaments but from different complexes: ESCRT-I-ALIX in plants and ESCRT-0 in humans ( xref )."
40157538
biogrid
No evidence text available
16431367
biogrid
No evidence text available
16730941
reach
"This preference is shared with STAM, whose binding to AMSH promotes its DUB activity and dictates the position of Ub cleavage (Baiady et al., 2016; Hologne et al., 2016)."
36825571
biogrid
No evidence text available
10982817
sparser
"To confirm that we have the minimal domains required for the AMSH-STAM interaction we carried out ITC and AUC experiments."
24151880
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"This is a clear indication that all of them use a similar mode of binding with SH3, while any modification of their sequence and/or length induces a change of binding kinetics and/or dissociation cons[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"We determined that the SH3 domain of STAM binds the catalytic domain of AMSH (AMSH219 E280A ) with a K D of 1.4 ± 0.04 µM ( xref and xref )."
24151880
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"The mammalian Hrs and STAM complex, equivalent to the Vps27 and Hse1 complex in budding yeast, binds two deubiquitinating enzymes, the JAMM and MPN+ family member AMSH (associated molecule with the SH3 domain of STAM) and the ubiquitin specific protease family member UBPY (ubiquitin isopeptidase Y)."
17660439
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"This depends upon AMSH binding to STAM, as it is abolished by introducing a mutation in the STAM binding motif (RKP) or by deleting the SH3 domain in STAM (not shown)."
16431367
sparser
"The ESCRT-0/AMSH interaction is achieved through the binding of the SH3 domain of STAM with the SH3 binding motif (SBM) of AMSH [5,18] , while the charged multivesicular body proteins (CHMPs) of ESCRT[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"Interestingly, the binding of STAM with AMSH increases its activity toward Lys63-linked polyubiquitin chains [5,23] ."
27725184
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"We wondered whether AMSH can interact simultaneously with STAM and mVps24."
16431367
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"Therefore, we asked if STAM can pull down mVps24 when coincubated with AMSH, through the direct association between AMSH and STAM."
16431367
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"Thus, the STAM-AMSH complex can bind up to three ubiquitin molecules (57)."
40157538
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"Importantly, this interaction is strongly enhanced by coincubation with AMSH, and reciprocally AMSH interaction with STAM is reinforced by mVps24, indicating that the complex is stabilized through a s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16431367
reach
"Hence, AMSH can simultaneously interact with both mVps24 and STAM, providing a direct connection between Hrs-STAM and ESCRTIII complexes."
16431367
biogrid
No evidence text available
16760479
reach
"Whereas human AMSH binds the ESCRT-0 subunit STAM, AMSH3 binds the ESCRT-I component VPS23A (127), suggesting that both human and plant AMSH proteins could be supporting nucleation of ESCRT-III filaments but from different complexes: ESCRT-I-ALIX in plants and ESCRT-0 in humans (Fig. 3)."
40157538
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"These targets were: eukaryotic translation initiation factor 4E [4E-BP1], adenosine deaminase [ADA], axin-1 [AXIN1], caspase-8 [CASP8], CD5, CD6, CUB domain-containing protein [CDCP1], extracellular newly identified receptor for advanced glycation end-products binding protein [EN.RAGE], signaling lymphocytic activation molecule 1 [SLAMF1], and signal-transducing adaptor molecule-binding protein [STAMBP] (marked “other targets” in Fig. 1)."
39362849
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"By providing an accessory ubiquitin binding site, this domain could increase the affinity of the AMSH and STAM complex for substrate."
16431367
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"We find that STAM also stimulates in vitro AMSH DUB activity toward EGFR immunoprecipitated from EGF stimulated cells, likewise dependent upon direct interaction between AMSH and STAM."
16431367
reach
"Both AMSH and Usp8 bind to ESCRT-0 protein STAM through a non canonical SH3 binding motif, and with their MIT-domain to several CHMP proteins of the ESCRT-III machinery [30,37,39,40]."
22800866
sparser
"While a consensus sequence is necessary for AMSH to bind the SH3 domain of STAM, we were interested to know how the length of this sequence could affect its interaction with SH3 and, hence, the deubiq[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
biogrid
No evidence text available
17078930
sparser
"A conserved interlog interaction between CHMP3 and AMSH was also observed in Drosophila melanogaster [28] and CHMP3 has been shown to form an in vitro complex with AMSH and STAM [34] ."
16730941
sparser
"STAM is closely associated with STAM-binding protein, STAMBP (also known as the associated molecule with the SH3 domain of STAM or AMSH), a metalloprotease and a member of the Jab1/MPN metalloenzyme (JAMM) family of DUBs xref ."
28492230
sparser
"We have confirmed a previously reported interaction between AMSH and STAM ( xref ), a protein which is in dynamic equilibrium between cytosol and endosomal membranes."
15314065
reach
"It seems that the weak interaction between STAM and AMSH does not change the conformation of STAM to help deubiquitination by AMSH, which only makes AMSH close enough to work on Ubs bound to STAM.We h[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17078930
biogrid
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15314065
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20159979
biogrid
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20159979
biogrid
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20159979
sparser
"Here, the AMSH-STAM interaction is conducted through the binding of the SH3 binding motif of AMSH to the SH3 domain of the STAM. xref "
28232880
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"AMSH has two SH3 binding motifs PXXP and interacts with STAM, a Jak3 associating adaptor, via these sites."
12943674
sparser
"It has been shown that AMSH interacts with the ESCRT-0 STAM-1 subunit and favours recycling of activated EGFR by promoting receptor deubiquitination."
33187263
sparser
"Importantly, this interaction is strongly enhanced by coincubation with AMSH, and reciprocally AMSH interaction with STAM is reinforced by mVps24, indicating that the complex is stabilized through a s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16431367
biogrid
No evidence text available
10383417
reach
"Previous studies have shown that once AMSH binds to STAM, its activity is enhanced, however, the precise mechanism is not known."
24151880
biogrid
No evidence text available
10383417
biogrid
No evidence text available
10383417
biogrid
No evidence text available
24151880
sparser
"AMSH interacts with the SH3 domain of STAM, a component of the MVB pathway that is constitutively associated with Hrs."
16431367
reach
"Since both Grb2 and STAM1 have been implicated in neuronal survival signaling [12-14], we speculate that the neuronal cell death in the AMSH deficient brain might be caused by the lack of interaction [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12810066
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24151880
biogrid
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12810066
sparser
"STAMBP interacts with the SH3 domain of STAM and transduces downstream signals from the Jaks-STAM complex."
29907875
hprd
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16730941
biogrid
No evidence text available
16520378
hprd
No evidence text available
10383417
sparser
"This depends upon AMSH binding to STAM, as it is abolished by introducing a mutation in the STAM binding motif (RKP) (B, g–i) or by deleting the SH3 domain in STAM (not shown)."
16431367
sparser
"AMSH–STAM interaction."
15314065
sparser
"Hence, AMSH can simultaneously interact with both mVps24 and STAM, providing a direct connection between Hrs-STAM and ESCRTIII complexes."
16431367
sparser
"Previous studies have shown that once AMSH binds to STAM, its activity is enhanced ( xref , xref ), however, the precise mechanism is not known ( xref )."
24151880
sparser
"We find that STAM also stimulates in vitro AMSH DUB activity toward EGFR immunoprecipitated from EGF-stimulated cells, likewise dependent upon direct interaction between AMSH and STAM (E)."
16431367
biogrid
No evidence text available
34102455
sparser
"Another study found that the AMSH–STAM interaction enhanced the deubiquitination of STAM-bound K63-linked ubiquitins."
18687060