IndraLab

Statements

reach
"TIMER database (http://timer.cistrome.org) and the Gene Expression Profiling Interactive Analysis (GEPIA) database (http://gepia.cancer-pku.cn/) were used to search the expression of OTUB2 in esophageal cancer; the GeneMANIA database (http://genemania.org/) was used to search the interaction between OTUB2 and YAP1/TAZ (WWTR1:TAZ also known as WWTR1)."
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"OTUB2 can both bind and deubiquitinate and thereby stabilize YAP and TAZ, particularly in cancer cells expressing oncogenic KRAS."
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reach
"OTUB2 can bind and stabilize YAP1/TAZ through ubiquitination, and has a certain positive regulatory effect on YAP1/TAZ."
35850645