IndraLab

Statements

USP15 binds SMAD6. 9 / 12
3 | 4 2
biogrid
No evidence text available
24850914
reach
"We show that USP15 interacts with SMAD6 and ALK3 and enhances BMP signalling by deubiquitylating ALK3 and rescuing it from proteasomal destruction."
24850914
reach
"FLAG-SMAD6, but none of the other FLAG-SMADs, was detected in USP15 IPs (XREF_FIG d), indicating the selective nature of the interaction between SMAD6 and USP15."
24850914
biogrid
No evidence text available
24850914
sparser
"The selective nature of the interaction between USP15 and SMAD6 prompted us to investigate a possible role for USP15 in BMP signalling."
24850914
reach
"Interestingly, the interaction between GFP-USP15 and HA-SMAD6 was completely abolished by FLAG-ALK3 overexpression (XREF_FIG b), suggesting that USP15 : SMAD6 and USP15 : ALK3 interactions could be mutually exclusive."
24850914
reach
"The selective nature of the interaction between USP15 and SMAD6 prompted us to investigate a possible role for USP15 in BMP signalling."
24850914
sparser
"FLAG-SMAD6, but none of the other FLAG-SMADs, was detected in USP15 IPs ( xref d ), indicating the selective nature of the interaction between SMAD6 and USP15."
24850914
biogrid
No evidence text available
24850914