IndraLab

Statements


USP19 decreases the amount of BAG6. 4 / 4
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"The reduction in BAG6 protein levels caused by USP19 knockdown was reversed after treatment with proteasome inhibitor MG132."

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"Knockdown of USP19 gene did not cause changes in BAG6 protein levels with lysosome inhibitor Chloroquine (CQ) (Figure S3B)."

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"Silencing and overexpressing USP19 significantly reduced BAG6 protein levels, despite having no effect on BAG6 mRNA levels (Figure 3F and Figure S3A), suggesting that USP19 regulates BAG6 not at the transcript but at the protein translation level."

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"Overexpression of USP19 significantly decreased ubiquitination of BAG6, but increased BAG6 protein level when compared with the control group (Figure 4A)."