IndraLab

Statements

USP14 decreases the amount of FASN. 9 / 9
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"Surprisingly, USP14 rather reduced the protein levels and activity of FASN in cancer cells, although it slightly inhibited the ubiquitination of FASN."
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"However, inhibition of both FASN and USP14 had no significant synergistic effect on cancer cell proliferation and, surprisingly, it was confirmed that USP14 negatively regulates the protein level and activity of FASN in cancer cells."
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"In LNCaP, MCF7 (human breast cancer cell), and A549 cell (human lung cancer cell), endogenous FASN protein levels were increased by USP14 knockdown contrary to the results in MPHs (Figure 2a)."
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"Surprisingly, USP14 rather reduced the protein levels and activity of FASN in cancer cells, although it slightly inhibited the ubiquitination of FASN."
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"Therefore, these findings demonstrated that USP14 negatively regulates protein levels and activity of FASN in cancer cells."
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"USP14 Negatively Regulates the Levels and Activity of FASN in Cancer Cells."
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"In addition, USP14 overexpression reduced the FASN protein level in cancer cells (Figure 2b)."
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"In future studies, the investigation of alterations in the transduction pathway of USP14 and FASN using transcriptomic analysis is warranted to understand not only the interaction between the two proteins but also the correlation of the interactomes.Taken together, the results reveal that USP14 negatively regulates FASN levels unexpectedly in the cancer cells, and as a result, inhibition of USP14 was not conducive to cancer cell death through inhibition of FASN."
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"Contrary to what we saw in the hippocampi, loss of USP14 reduced the levels of FASN, RELA, and CTNNB1 but did not alter the level of SNAP23 in the livers of the ax mice (Figure 7c,d)."
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