IndraLab

Statements

TRPV1 binds TNF. 12 / 12
| 4 8
sparser
"In this study, we examine the interactions of TRPV1 and TNF for pain processing after intrathecal administration of RTX by using behavioral tests and detection of protein levels in DRG neurons of rats."
28831207
sparser
"TNF- α can bind to TRPV1, thus regulating the current of the voltage-gated sodium channel, inducing the continuous potential of the sensory nerve, increasing the current in the nerve fibers, and causing pain [ xref ]."
35800014
sparser
"TNF-α is also reported to sensitize TRPV1 in the spinal cord and trigeminal neurons. xref , xref , xref Although the precise interaction between TNF-α and TRPV1 expressed in the visceral neurons is not fully understood, TNF-α targeting therapy may also change pain perception via TRPV1."
36777266
sparser
"The TRPV1 and TNF pathways interact and cross-act in cell signal transduction and the inflammatory response."
39770536
reach
"Although the precise interaction between TNF-α and TRPV1 expressed in the visceral neurons is not fully understood, TNF-α targeting therapy may also change pain perception via TRPV1."
36777266
sparser
"Previous studies suggest interactions between TNF and TRPV1, resulting in a modulation of ion channel function and protein expression in the pathophysiology of inflammatory and neuropathic pain [ xref , xref , xref ]."
28831207
sparser
"For instance, TRPV1 activity is clearly associated with tumor necrosis factor-α (TNF-α)-induced monoarthritis [ xref , xref ]."
24396340
sparser
"In fact, TRPV1 shows an increase in expression after prior treatment with TNF-α in cultured fibroblast-like synoviocytes [ xref ], suggesting a direct interaction of TNF-α and TRPV1."
29444083
reach
"In fact, TRPV1 shows an increase in expression after prior treatment with TNF-α in cultured fibroblast-like synoviocytes [53], suggesting a direct interaction of TNF-α and TRPV1."
29444083
sparser
"It is undeniable that TRPV1 is tightly associated with TNF-α, and blocking the reciprocal relationship may reduce the inflammatory response in RA patients, and may also delay bone destruction, diminish disability and improve the quality of patient survival."
37744324
reach
"TNF-α can bind to TRPV1, thus regulating the current of the voltage-gated sodium channel, inducing the continuous potential of the sensory nerve, increasing the current in the nerve fibers, and causing pain [32]."
35800014
reach
"Previous studies suggest interactions between TNF and TRPV1, resulting in a modulation of ion channel function and protein expression in the pathophysiology of inflammatory and neuropathic pain [17, 19, 20]."
28831207