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Melatonin inhibits RELA. 14 / 15
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"3.3 Melatonin inhibits NF-kappaB and p65 signaling in thyroid cancer."
29525603
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"In contrast, dietary supplementation with MT significantly down-regulated the T-2 toxin-induced elevation of pro-inflammatory cytokines mRNA levels and decreased the p-IκBα/IκBα and p-p65/p65 ratios i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To determine whether melatonin inhibits NF-kappaB and p65 signaling in thyroid cancer, the total and nuclear portions of 8505c and TPC-1 cells were isolated after treatment with different concentrations of melatonin."
29525603
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"Our results showed that melatonin treatment inhibited NF-kappaB p65 activation."
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"In addition, melatonin decreased TNBS induced up-regulation of TLR4, MyD88, and NF-kappaB p65, and increased down-regulation of I-kappaB proteins."
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"In the present study , melatonin reduced NF-kappaB p65 expression , which may be the key mechanism underlying the effects of melatonin on the treatment of nicotine-related AAA ."
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"Furthermore, MT inhibited the transfer of NF-kappaB p65 into the nucleus and the phosphorylation of IkappaBalpha."
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"Moreover, melatonin prevented NF-κB p65 from attaching to the COX-2 promoter."
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"As a result, melatonin could inhibit the NF-κB p65/COX-2 signalling pathway in the MLL-r cell lines."
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"In the present study, melatonin administration to rats with cerulein-induced pancreatitis significantly decreased the NF-κB p65 immunopositive cell percentages and apoptotic cell numbers in pancreatic tissue."
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"Further analysis demonstrated that melatonin significantly reduced p65 activation and the release of inflammatory factors."
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"Herein, we showed that melatonin inhibited the activation of p65 in the testes of the stressed mice as well as in H 2 O 2 -treated testicular cells."
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"As shown in Fig. 5 D, The results indicated that treatment with melatonin for 48 h markedly inhibited the binding of NF-κB p65 subunit to the COX-2 promoter."
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"However, melatonin pre-treatment reduced the nuclear localization of p65 and degradation of IκBα ( Fig. 8 B)."
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