IndraLab

Statements

HDAC5 activates USP28. 5 / 5
| 5
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"Both LSD1 and histone deacetylases (HDACs) facilitate breast cancer proliferation, and interestingly, HDAC5 could promote the stability of USP28."
29415985
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"Chunyu Cao et al. reported that HDAC5 directly interacted with and stabilized the LSD1 protein, and HDAC5 promoted the stability of USP28 thus indirectly preventing the ubiquitination-dependent degradation of LSD1 in breast cancer cell lines ."
39379699
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"We further demonstrated that HDAC5 promoted the protein stability of USP28, a bona fide deubiquitinase of LSD1."
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"Alternatively, histone deacetylase 5 (HDAC5) promotes USP28 stability and positively regulates the protein abundance of the Lysine-specific histone demethylase 1A (LSD1) [19]."
| PMC
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"As reported by Chunyu Cao et al., HDAC5 directly interacted with and stabilized the LSD1 protein, and HDAC5 promoted the stability of USP28 thus indirectly preventing the ubiquitination-dependent degradation of LSD1 in breast cancer cell lines ."
39379699