IndraLab

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Spironolactone decreases the amount of HCN4. 3 / 3
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"Compared with the MI group, spironolactone significantly decreased the HCN4 mRNA expression in ischemic left ventricular myocardium by 16% (P < 0.05)."
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"Compared with the MI group, spironolactone significantly downregulated the HCN2 and HCN4 protein expression in ischemic left ventricular myocardium by 50% and 52%, respectively (P < 0.05)."
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"In this study, we found that spironolactone significantly reduced HCN4 protein expression in rat ischemic left ventricular myocardium after MI, in agreement with Song et al.."
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