IndraLab

Statements

Silibinin inhibits JUN. 4 / 4
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"Silibinin significantly inhibited xenograft tumor growth in nude mice, with no obvious toxicity.Conclusions: Silibinin considerably reduced the development of oral cancer cells by inducing apoptosis, G 0 /G 1 arrest, ROS generation, and activation of the JNK/c-Jun pathway."
37476191
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"However, silibinin could inhibit c-Jun activation without affecting the activation of JNK, this could be a result from complex cross-talking of signaling pathways."
16169542
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"Consistent with its effects on COX2 and iNOS, similar silibinin treatments also inhibited UVB caused NF-kappaB and STAT3 activation in both skin and skin tumors [XREF_BIBR]; silibinin also strongly inhibited the activation of transcription factor AP-1 [XREF_BIBR]."
26097804
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"Silibinin decreased the gp130, EGFR, p-STAT3, STAT3, AKT, p-c-Jun, fibronectin, N-cadherin, and Snail proteins; increased the IL-6, p-AKT, and KLF4 proteins; and had no effect on G6PD in TC28a2 cells (Figure 1B)."
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