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NFE2L2 decreases the amount of USP21. 2 / 2
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"However, in H/R-challenged HepG2 cells, luciferase reporter expression was markedly induced by H/R while greatly inhibited by Nrf2 overexpression, indicating that Nrf2 requires the actions of other transcription factors to repress expression of the USP16 gene (Fig. 8F)."
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"Interestingly, our work found that Nrf2 elevated luciferase reporter expression from USP16-WT, but inhibited luciferase reporter expression from USP16 under H/R conditions, suggesting that Nrf2 suppresses the mRNA level of USP16, and it may need other transcription factors to achieve the functions."
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