IndraLab

Statements

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"Fourth, although we determined that OTUB2 promoted glycolysis and increased the lactate content in VSMCs, we did not investigate whether OTUB2 regulates histone lactylation levels during VC progression."
39776804
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"In conclusion, circRNA6448-14 sponged miR-455-3p, which in turn promoted OTUB2 expression, thereby enhancing glycolysis and stemness of ESCC cells."
38819228
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"In colon cancer, Yu et al. [14] demonstrated that OTUB2 promotes the malignant progression of colorectal cancer by enhancing PKM2 activity and glycolysis."
39210373
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"The overexpression of OTUB2 promoted glycolysis and induced the proliferation, migration, and invasion of endometrial cancer cells."
36316812
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"Furthermore, the increased glycolysis and decreased OXPHOS mediated by OTUB2 silencing could be effectively reversed by the expression of shRNA-resistant wild-type OTUB2 (SI Appendix, Fig. S4 G–L)."
38701117
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"Recent studies have demonstrated that OTUB2 promotes the progression of colorectal cancer by facilitating glycolysis [14]."
39210373
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"We assessed the extracellular acidification rate (ECAR) of VSMCs using an XFe96 extracellular flux analyzer to further explore whether OTUB2 mediates glycolysis through PFKFB3."
39776804
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"Finally, we revealed that circRNA6448-14 promoted OTUB2 expression and enhanced ESCC glycolysis and stemness by competitively binding to miR-455-3p."
38819228
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"In addition, the deubiquitinase OTUB2 enhances glycolysis to aggravate the progression of CRC [27,29]."
38585643
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"Here we demonstrate that OTUB2, an OTU deubiquitinase, is upregulated in colorectal cancer (CRC) and exacerbates the progression of CRC through modulating the aerobic glycolysis."
34671086
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"In colon cancer, OTUB2 interacts with PKM2, enhancing its activity and promoting glycolysis, thereby facilitating colorectal cancer progression [36]."
39380010
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"Overexpression of OTUB2 enhanced glycolysis and promoted cell growth, migration, and invasion via the AKT/mTOR signaling pathway in A549 and H1299 cells and a xenograft mouse model (Li J. et al., 2019)."
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"Our results showed that OTUB2 could be stabilized by TRIM47, and the overexpression of OTUB2 rescued the inhibition of cell proliferation and aerobic glycolysis mediated by TRIM47 downregulation."
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