IndraLab

Statements

BAP1 binds KMT2C and KDM6A. 2 / 2
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"Mutations within the MLL3 PHD domains abolish the interaction between the BAP1 tumor suppressor complex and MLL3-UTX, which leads to attenuation of enhancer activity."
30753822
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"We found that cancer hotspot mutations in the MLL3 amino terminal PHD repeats disrupt its association with the BAP1 complex and result in reduced MLL3 and UTX recruitment to enhancers misregulating the epigenetic chromatin state at these loci."
29785026