IndraLab

Statements

CSPalpha activates KCNMA1. 5 / 5
| 5
reach
"In parallel experiments, these observed CSPalpha mediated changes in cell surface BK channel density and were confirmed by cell surface biotin labeling, followed by streptavidin pull-down and Western analysis (refer to inset)."
24475152
reach
"In order to directly examine such an effect of wild-type CSPalpha, we utilized an expression strategy to force an imbalance between BK channels and endogenous CSPalpha, thereby allowing BK channel protein to be present at elevated levels so that decreases in BK channel density induced by CSPalpha could be precisely monitored."
24475152
reach
"It is possible that the CSPalpha induced regulation of BK channel current represents a key event contributing to the CSPalpha mediated synapse protection."
24475152
reach
"We speculate that CSPalpha directly modulates BK channel density, nonetheless this is not a foregone conclusion."
24808827
reach
"Additionally, reduced CSPalpha expression is expected to increase BK channel density at synapses, which reduces excitability at presynaptic terminals [XREF_BIBR, XREF_BIBR]."
25631211