IndraLab

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CSPalpha activates KCNMA1. 5 / 5
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"In parallel experiments, these observed CSPalpha mediated changes in cell surface BK channel density and were confirmed by cell surface biotin labeling, followed by streptavidin pull-down and Western analysis (refer to inset)."
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"We speculate that CSPalpha directly modulates BK channel density, nonetheless this is not a foregone conclusion."
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"In order to directly examine such an effect of wild-type CSPalpha, we utilized an expression strategy to force an imbalance between BK channels and endogenous CSPalpha, thereby allowing BK channel protein to be present at elevated levels so that decreases in BK channel density induced by CSPalpha could be precisely monitored."
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"Additionally, reduced CSPalpha expression is expected to increase BK channel density at synapses, which reduces excitability at presynaptic terminals [XREF_BIBR, XREF_BIBR]."
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"It is possible that the CSPalpha induced regulation of BK channel current represents a key event contributing to the CSPalpha mediated synapse protection."
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