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Sodium(1+) activates KCNK2. 2 / 3
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"Sodium nitroprusside (10 (-6) or 10 (-5) m) and 8-Br-cGMP (10 (-4) or 10 (-3) m) increased TREK-1 currents in perforated whole cell and single channel recordings."
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"TREK-1 is " activated " by extracellular sodium (Fink etal, 1996), accordingly, replacing extracellular Na + by NMDG + strongly reduced wild-type TREK-1 outward currents (Fig XREF_FIG D)."
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