IndraLab

Statements

FHND004 inhibits KCNH2. 4 / 4
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"Therefore, these results illustrated an open channel block of hERG by FHND004."
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"In this study, our results elucidated that FHND004 was able to directly block hERG channels in a time- and concentration dependent manner."
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"FHND004 inhibited hERG K + currents in a concentration dependent manner with IC 50 values of 8.46 +/- 0.33 muM in HEK293 cells and 7.52 +/- 1.27 muM in HL-1 cells, respectively."
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"Overall, FHND004 is able to directly block hERG channels at open state but shows less potency for inhibiting the channels than the marketed AZD9291."
29904349