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USP10 inhibits cell growth. 18 / 19
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"In addition, USP10 suppresses the tumour cell growth in cells with wild-type p53, and USP10 expression is down-regulated in a high percentage of clear cell carcinomas known to have few p53 mutations [108]."
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"Downregulation of p53 abolished the inhibitory effect of USP10 on tumor growth (XREF_FIG and data not shown), confirming that USP10 inhibits cancer cell growth by stabilizing p53."
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"In addition, USP10 suppresses the tumour cell growth in cells with wild-type p53, and USP10 expression is down-regulated in a high percentage of clear cell carcinomas known to have few p53 mutations [XREF_BIBR]."
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"Given USP10 also regulates p53 expression and suppresses tumor cell growth, phosphorylation of USP10 under energy stress might contribute to p53 level increase and tumor suppression."
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"On the other hand, shRNA mediated USP10 knockdown caused more vigorous tumor cell growth of both wildtype and p53-null cells, confirming the tumor-suppressive function of USP10 (XREF_FIG, XREF_SUPPLEMENTARY)."
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"Moreover, USP10 inhibited cell growth and invasion in lung cancer [XREF_BIBR], and was an independent factor for the prognosis of gastric carcinoma [XREF_BIBR]."
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"Consistent with this study, we show that increased USP10 expression in mutant p53 background increases p53 levels and promotes cancer cell proliferation, while downregulation of USP10 inhibits cancer cell growth."
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"Our study demonstrated that USP10 suppresses tumor cell growth through potentiating both SIRT6- and p53 mediated suppression of the oncogene c-myc."
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"The same study shows that USP10 suppresses tumor cell growth in cells expressing wild-type p53."
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"For example, USP10 inhibits lung cancer cell growth and invasion."
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"Therefore, USP10 suppresses colon cancer cell growth through both SIRT6 and p53."
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"Finally, USP10 suppresses tumor cell growth in cells with wild-type p53, with USP10 expression downregulated in a high percentage of clear cell carcinomas, known to have few p53 mutations."
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"USP10 inhibits lung cancer cell growth and invasion by upregulating PTEN."
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"On the other hand, SIRT6 knockdown partially abolished the suppressive activity in cancer cell growth by USP10 expression in p53 wildtype, but not p53-null colon cancer cells (XREF_FIG, XREF_SUPPLEMENTARY)."
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"3.2 Spautin-1, a dual USP10 and USP13 antagonist, inhibits melanoma cell growth in vitro."
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"Hence, USP10 suppresses tumor cell growth in cells with wildtype p53."
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"However , in lung cancer , USP10 can inhibit cell growth and invasion by stabilizing PTEN , suggesting that the roles of USP10 in the different cancer types are distinct [ 51 ] ."
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"Given USP10 also regulates p53 expression and suppresses tumor cell growth (Yuan et al., 2010), phosphorylation of USP10 under energy stress might contribute to p53 level increase and tumor suppressio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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