IndraLab

Statements

Cisplatin inhibits CHUK. 4 / 4
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"Following knockdown of IKKalpha and IKKbeta, HN13 cells were treated with cisplatin (5 mug/ml) and stained with Hoechst 33342."
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"HN13 cells were sensitized to 5mug/ml of cisplatin following suppression of IKKalpha and IKKbeta compared to 12.5 mug/ml of cisplatin when transfected with scramble siRNA (XREF_FIG A lower panel)."
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"We do not know if the increased sensitivity to cisplatin following suppression of IKKalpha and IKKbeta was a direct effect of low levels of NFkappaB or a consequence of chromatin acetylation induced by siRNA interference of the NFkappaB signaling."
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"Following suppression of IKKalpha and IKKbeta with siRNA, HN13 cells were treated with TSA, cisplatin, or vehicle and lysed."
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