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COPS6 decreases the amount of CDKN2A. 4 / 4
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"We then examined whether CSN6 reduced the expression of p16 through E3 ubiquitin ligases."
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"Thus, these observations present a paradox: How does CSN6 reduce p16 expression?"
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"CSN6 promoted the loss of p16-mediated tumor progression and played an important role in regulating ubiquitin-independent proteasomal degradation of p16."
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"Although the results showed that there was no significant change in the p21 in both cell lines (Figure 3A), it was shown that CSN6 could downregulate the steady-state expression of endogenous p16 in a dose-dependent manner in GC cells (Figure 3B)."
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