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NAMPT phosphorylates INSR. 12 / 12
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"In contrast others found that Nampt did not induce insulin receptor phosphorylation or downstream AKT activity when tested on several preadipocyte cell lines XREF_BIBR."
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"Visfatin induces phosphorylation of the IR and IR substrates 1 and 2 in human osteoblasts and in human adipocytes in vitro [31,11] ."
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"Later, Nampt insulin-like effects were observed in human osteoblasts whereas Nampt induced tyrosine phosphorylation of IR, IRS-1, and IRS-2 in a close resemblance to insulin action [16,17] ."
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"Furthermore, visfatin induced tyrosine phosphorylation of the insulin receptor, activated downstream insulin signaling pathways such as Erk-1, Akt, and p38 MAPK, and markedly increased the levels of TGFbeta1, PAI-1, type I collagen, and MCP-1 in both renal cells."
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"Visfatin induces phosphorylation of the IR and IR substrates 1 and 2 in human osteoblasts and in human adipocytes in vitro [31,11] ."
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"In the same study, the authors demonstrated that visfatin phosphorylated the insulin receptor, insulin receptor substrate-1 (IRS-1) and -2 (IRS-2), PI3K, Akt and MAPK [ xref ]."
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"We found that visfatin induced tyrosine phosphorylation of IR, IRS-1, and IRS-2."
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"In the same study, the authors demonstrated that visfatin phosphorylated the insulin receptor, insulin receptor substrate-1 (IRS-1) and -2 (IRS-2), PI3K, Akt and MAPK [XREF_BIBR]."
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"Visfatin has been demonstrated to modulate INS secretion, INSR phosphorylation, intracellular signaling, and the expression of multiple mouse β-cell function-associated genes via INSR and ERK1/2 [64]."
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"It is therefore imperative to identify the factors and mechanisms regulating placental proliferation and apoptosis in order to abrogate numerous pregnancy pathologies.We found that visfatin modulated INSR and ERK1/2, AKT, AMPKα, and STAT3 phosphorylation."
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"In contrast others found that Nampt did not induce insulin receptor phosphorylation or downstream AKT activity when tested on several preadipocyte cell lines xref ."
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"Although insulin (10 nM) induced significant phosphorylation of the insulin receptor and the downstream signaling kinase Akt in each of these cell lines, equimolar concentrations of eNampt and visfati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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