IndraLab

Statements


BAP1 deubiquitinates INO80. 6 / 6
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"In line with this notion, BAP1 depletion resulted in reduced localization of RPA, RAD51 and BRCA1 to IRIF or microlaser irradiation site [100,101], although it remains ambiguous whether either histone[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"In addition to MCRS1, a recent study revealed that BAP1 deubiquitinates and stabilizes Ino80, a key subunit of the INO80 chromatin remodeling complex implicated in DNA replication during stress."

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"BAP1 overexpression also abolished basal Ino80 ubiquitination (XREF_FIG and XREF_FIG, rightmost lanes)."

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"BAP1 interacts with and deubiquitylates INO80, playing a critical role in stabilizing and targeting the INO80 chromatin remodeling complex to the replication forks."

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"Since BAP1 deubiquitinates and stabilizes Ino80, we investigated the relationship between CHIP and BAP1 in Ino80 ubiquitination."

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"BAP1 deubiquitylates INO80 and thereby protects the protein from ubiquitin mediated proteolysis."