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Baicalein inhibits TMPRSS2. 2 / 2
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"It is interesting to note that several derivatives of SB, including scutellarin, baicalein, wogonin, and luteolin have also been reported to inhibit M pro and TMPRSS2 (please see discussion), which provides a scientific basis for the SB to inhibit SARS-CoV-2 infection.Viruses 2021, 13, x FOR PEER REVIEW individual constituent compounds were determined by mass spectrometry."
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"Mechanism dissection suggest that baicalein can suppress AR target genes (PSA, TMPRSS2, and TMEPA1) expression in both androgen responsive LNCaP cells and castration resistant CWR22Rv1 cells, that may involve the inhibiting the AR N/C dimerization and AR-coactivators interaction."
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