IndraLab

Statements

Baicalein inhibits TMPRSS2. 3 / 3
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"In addition, baicalein inhibits the activity of host TMPRSS2 protease and viral Nsp14."
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"Mechanism dissection suggest that baicalein can suppress AR target genes (PSA, TMPRSS2, and TMEPA1) expression in both androgen responsive LNCaP cells and castration resistant CWR22Rv1 cells, that may involve the inhibiting the AR N/C dimerization and AR-coactivators interaction."
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"In addition, TMPRSS2 enzyme might be inhibited by baicalein, which might be another mechanism of action by which baicalein exerts its anti-SARS-CoV-2 effect (Pooja et al. 2021)."
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