IndraLab

Statements

Dihydrogen activates KCNH2. 3 / 3
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"Tightening of a Hydrogen Bond Induces Collapse of the hERG Selectivity Filter."
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"However, our results also emphasize that presence of one hydrogen bond acceptor group at a certain distance from a hydrophobic group within a chemical scaffold may increases the hERG liability (IC 50)."
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"Proton block of the pore underlies the inhibition of hERG cardiac K+ channels during acidosis."
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