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OTUD5 inhibits SPT16. 1 / 1

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"Consistent with the roles of Fanconi Anemia proteins in CFS stability (50) and limiting aberrant R-loop formations (21,22), depletion of FANCD2 was synthetically lethal with loss of FACT regulation in the OTUD5 cells.A previous study showed that depleting SPT16 increases DNA–RNA hybrids and genomic instability in yeast and human cells (35)."

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OTUD5 inhibits SPT16. 1 / 1

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