IndraLab

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LBT activates USP32. 3 / 3
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"Taken together, these results revealed that LBT triggered ferroptosis in LUSC cells in vivo by targeting the USP32–NRF2 axis."
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"As expected, the heat challenge quickly led to USP32 denaturation and precipitation, while LBT markedly increased the thermal stability of the USP32 protein at temperatures ranging from 42 °C to 54 °C (Figure 3F), confirming the direct binding of LBT to USP32."
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"To validate whether LBT induces ferroptosis by targeting USP32, we established the stable overexpression of USP32 in H520 and H1703 cells using lentivirus infection."
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