IndraLab

Statements

USP37 activates BLM. 4 / 4
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"Mechanistically, DNA damage activates ATM which phosphorylates USP37 and activates its deubiquitinase activity to stabilize BLM."
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"USP37 promotes BLM stabilization."
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"USP37-promoted BLM stabilization is potentiated by DNA damage."
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"Interestingly, WT USP37 was phosphorylated by ATM, which in turn increased its deubiquitination activity towards BLM, while the S114A mutant did not have this effect."
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