IndraLab

Statements

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"Overall, these data indicate that the inhibition of Aurora kinases and RIPK1 by Tozasertib and its analogues is correlated to the proliferation and cytokinesis defects and necroptosis protection, respectively."
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"Finally, Tozasertib inhibited recombinant human RIPK1, human Aurora A and human Aurora B kinase activity, but not RIPK3."
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"Finally, Tozasertib inhibited recombinant human RIPK1, human Aurora A and human Aurora B kinase activity, but not RIPK3."
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"Although Tozasertib inhibits RIPK1 dependent apoptosis in MEF cells, its inhibition on RIPK1 dependent necroptosis in the same cells is remarkably less effective."
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"Finally, Tozasertib also blocks RIPK1 dependent necroptosis in the human HT29 cell line with an IC50 of 0.26 microM."
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"Overall, these data indicate that the inhibition of Aurora kinases and RIPK1 by Tozasertib and its analogues is correlated to the proliferation and cytokinesis defects and necroptosis protection, respectively."
29434255