IndraLab

Statements

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"Although Tozasertib inhibits RIPK1 dependent apoptosis in MEF cells, its inhibition on RIPK1 dependent necroptosis in the same cells is remarkably less effective."
29434255
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"Overall, these data indicate that the inhibition of Aurora kinases and RIPK1 by Tozasertib and its analogues is correlated to the proliferation and cytokinesis defects and necroptosis protection, respectively."
29434255
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"Finally, Tozasertib also blocks RIPK1 dependent necroptosis in the human HT29 cell line with an IC50 of 0.26 microM."
29434255
tas
No evidence text available
22037378
sparser
"Finally, Tozasertib inhibited recombinant human RIPK1, human Aurora A and human Aurora B kinase activity, but not RIPK3."
29434255
tas
No evidence text available
18183025
sparser
"Overall, these data indicate that the inhibition of Aurora kinases and RIPK1 by Tozasertib and its analogues is correlated to the proliferation and cytokinesis defects and necroptosis protection, respectively."
29434255
reach
"Finally, Tozasertib inhibited recombinant human RIPK1, human Aurora A and human Aurora B kinase activity, but not RIPK3."
29434255
tas
No evidence text available
29437386