IndraLab

Statements

OTUD6B decreases the amount of SNAI1. 3 / 3
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"In support of the notion that OTUD6B enhances β‐TrCP protein stability and thus decreases SNAIL protein level, we found a significant positive correlation between OTUD6B and β‐TrCP protein levels in ESCC tissues (Figure 5C) and a negative correlation between OTUD6B and SNAIL protein levels (Figure 5D)."
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"Consistent with the notion that OTUD6B enhances β‐TrCP protein stability and decreases SNAIL protein level, ATRA treatment upregulated the level of β‐TrCP and downregulated the expression of SNAIL (Figure 6A)."
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"Knockdown of OTUD6B increases SNAIL expression through decreasing β‐TrCP protein stability, and accelerates ESCC tumor progression through the OTUD6B‐β‐TrCP‐SNAIL axis (Figure 7L)."
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