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Disulfiram inhibits CASP1. 2 / 2

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"In a fluorogenic caspase activity assay that measures the release of 7-amino-4-methylcoumarin (AMC) from the inflammatory caspase substrate Ac-YVAD-AMC, disulfiram indeed inhibited recombinant caspase-1 and caspase-11 with IC 50 of 0.15 +/- 0.04 muM and 0.73 +/- 0.07 muM, respectively (XREF_FIG - XREF_FIG)."

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sparser

"A study reported in 1997 showed potent caspase-1 inhibition by disulfiram [ xref ], which would block pro–IL-18 maturation."

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Disulfiram inhibits CASP1. 2 / 2

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