IndraLab

Statements

Disulfiram inhibits CASP1. 6 / 6
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"Interestingly, disulfiram has also been shown to inhibit caspase-1 at submicromolar concentrations in a slow-binding reaction with an apparent k on of 2.2 × 10 3 M −1 s −1 [24] , possibly through the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28887129
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"Subsequent studies showed that disulfiram inhibited caspase 1, caspase 11, and the ring form of GsdmD-N by covalently attaching to the catalytic cysteines of caspases 1 and 11, and to the cysteine (human/mouse Cys191/Cys192) within the channel of the GsdmD-N pore xref , xref ."
34589396
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"A study reported in 1997 showed potent caspase-1 inhibition by disulfiram [ xref ], which would block pro–IL-18 maturation."
25963312
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"In a fluorogenic caspase activity assay that measures the release of 7-amino-4-methylcoumarin (AMC) from the inflammatory caspase substrate Ac-YVAD-AMC, disulfiram indeed inhibited recombinant caspase-1 and caspase-11 with IC of 0.15 ± 0.04 μM and 0.73 ± 0.07 μM, respectively (Extended Data Fig. 3a–d)."
32367036
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"There is no evidence that ritonavir would adversely influence healing of any concurrent injuries the subject had.There exists a single report that the alcoholism treatment drug disulfiram, introduced [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19004566
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"Subsequent studies showed that disulfiram inhibited caspase 1, caspase 11, and the ring form of GsdmD-N by covalently attaching to the catalytic cysteines of caspases 1 and 11, and to the cysteine (human/mouse Cys191/Cys192) within the channel of the GsdmD-N pore119 120."
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