IndraLab

Statements

USP14 activates TARDBP. 4 / 4
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"Intriguingly, Lee et al. demonstrated that IU1, a selective small-molecule inhibitor of USP14, accelerated proteasomal degradation of tau and TDP-43, which have been implicated in neurodegenerative diseases XREF_BIBR."
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"It has been shown that proteasome-associated USP14 deubiquitinates TDP-43 and that USP14 inhibition accelerates TDP-43 turnover."
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"Conversely, a selective inhibitor of USP14, IU1, promoted degradation of overexpressed tau, TDP-43 and ataxin-3 [XREF_BIBR]."
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"Although pharmacological inhibitors of USP14's ubiquitin-hydrolase activity reduced microtubule associate protein tau, tar DNA binding protein, and prion protein in culture, the effect was similar in wild type and USP14-deficient neurons, thus impacting their use for specifically evaluating USP14 in a therapeutic manner."
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