IndraLab

Statements

OTUB2 is ubiquitinated. 4 / 4
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"Given that PbE3‐2 ubiquitinates RD21A and OTU2 interacts with RD21A, we hypothesized that OTU2 may interfere with the interaction between PbE3‐2 and RD21A. The Y3H experiment results supported this hypothesis, showing that OTU2 blocks the interaction between PbE3‐2 and RD21A. As shown in Figure  xref , yeast colonies carrying the PbE3‐2 and RD21A constructs grew on the defective medium, whereas colonies with an additional OTU2 construct did not, indicating that OTU2 disrupts this interaction."
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"We next set out to identify which amino acid(s) is/are ubiquitinated in GFP-OTUB2."
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"In the present study, we provided mechanistic insights into TRIM47 as an important regulator of the Warburg effect by its inhibition of OTUB2’s ubiquitination."
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"Altogether these data demonstrate that OTUB2 is ubiquitinated via lysine 31 and that inactivation of OTUB2 by catalytic site mutation or inhibitor treatment leads to elevated monoubiquitination."
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