IndraLab

Statements

COPS5 inhibits SIAH1. 3 / 3
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"Moreover, JAB1 was also reported to promote degradation of seven in absentia homolog-1 (SIAH-1) and activate β-catenin pathway via its deNEDDylase activity (Jumpertz et al. 2014)."
37365502
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"Recent studies have revealed that JAB1 knockdown downregulates total β-catenin expression in human CRC cells [ 7 ], and JAB1 overexpression enhances the degradation of SIAH-1, a putative E3 ubiquitin [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32977947
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"Silencing RNA knockdown or overexpression of CSN5 revealed that CSN5 promotes SIAH-1 expression, while CSN5 knockdown also attenuated SIAH-1 protein degradation."
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