IndraLab

Statements

USP4 ubiquitinates MAP3K7. 2 / 2
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"Overexpression of wild-type USP4 in Hela cells can inhibit TAK1 polyubiquitination and NF-κB activation, whereas its knockdown can enhance polyubiquitination of TAK1 and phosphorylated IκBα and negatively regulate NF-κB activation induced by IL-1β, LPS and TGFβ (154)."
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reach
"It has been reported that USP4 acts as a negative regulator to inhibit IL-1β-, LPS- and TGF-β-induced NF-κB activation by deubiquitinating TAK1 [45]."
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